PHA.03537.03 - Purification of products of pharmaceutical biotechnology (Downstream Processing) (Vollständige Modulbeschreibung)
| PHA.03537.03 | 10 CP |
|---|---|
| Modulbezeichnung | Purification of products of pharmaceutical biotechnology (Downstream Processing) |
| Modulcode | PHA.03537.03 |
| Semester der erstmaligen Durchführung | |
| Fachbereich/Institut | Institut für Pharmazie |
| Verwendet in Studiengängen / Semestern |
|
| Modulverantwortliche/r | |
| Weitere verantwortliche Personen |
Prof. Dr. M. Pietzsch |
| Teilnahmevoraussetzungen | Module C: Construction of production organisms; Module D: Introduction to bioprocess technology |
| Kompetenzziele | Knowledge of the basic concepts of downstream processing Foundations of protein purification Knowledge on equipment and design parameters Knowledge of scale-up parameters Challenges in prevention or elimination of contaminants Knowledge on process integration: Strain development, up- and downstream processing Bbasics of technical/industrial purification of proteins Know how to plan and perform the purification of a target protein from biomass |
| Modulinhalte | Course G.1: Introduction to Downstream Processing Overview on potential contaminations of target products and strategies for their removal Equipment: Design and operation Cell disintegration Solid-Fluid separations Liquid-Liquid extraction Precipitation and crystallization Chromatographic separations Special applications: Purification of membrane proteins, inclusion bodies, antibodies, vi-ruses, DNA, etc. Course G.2: Practical course on Downstream Processing Purity control by SDS-PAGE and determination of specific enzymatic activity Cell disintegration Solid / Liquid Separation Protein precipitation Preparative chromatography for the purification of proteins Packing of chromatography columns Generation of purification tables |
| Lehrveranstaltungsformen |
Vorlesung (2 SWS)
Seminar (1 SWS) Seminar (1 SWS) Praktikum (4 SWS) Kursus |
| Unterrichtsprachen | Deutsch, Englisch |
| Dauer in Semestern | 1 Semester Semester |
| Angebotsrhythmus Modul | jedes Sommersemester |
| Aufnahmekapazität Modul | unbegrenzt |
| Prüfungsebene | |
| Credit-Points | 10 CP |
| Modulabschlussnote | LV 1: %; LV 2: %; LV 3: %; LV 4: %; LV 5: %. |
| Faktor der Modulnote für die Endnote des Studiengangs | 1 |
| Modulveranstaltung | Lehrveranstaltungsform | Veranstaltungstitel | SWS | Workload Präsenz | Workload Vor- / Nachbereitung | Workload selbstgestaltete Arbeit | Workload Prüfung incl. Vorbereitung | Workload Summe |
|---|---|---|---|---|---|---|---|---|
| LV 1 | Vorlesung | Introduction to Downstream Processing | 2 | 0 | ||||
| LV 2 | Seminar | Introduction to Downstream Processing | 1 | 0 | ||||
| LV 3 | Seminar | Practical course on Downstream Processing | 1 | 0 | ||||
| LV 4 | Praktikum | Practical course on Downstream Processing | 4 | 0 | ||||
| LV 5 | Kursus | Selbststudium | 0 | |||||
| Workload modulbezogen | 300 | 300 | ||||||
| Workload Modul insgesamt | 300 | |||||||
| Prüfung | Prüfungsvorleistung | Prüfungsform | |
|---|---|---|---|
| LV 1 | |||
| LV 2 | |||
| LV 3 | |||
| LV 4 | |||
| LV 5 | |||
| Gesamtmodul | 1 attestation, 1 presentation, 1 protocol on lab course |
Klausur |
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| Wiederholungsprüfung | |||
| Regularien | Teilnahmevoraussetzungen | Angebotsrhythmus | Anwesenheitspflicht | Gewicht an Modulnote in % |
|---|---|---|---|---|
| LV 1 | Sommersemester | Nein | % | |
| LV 2 | Sommersemester | Nein | % | |
| LV 3 | Sommersemester | Nein | % | |
| LV 4 | Sommersemester | Nein | % | |
| LV 5 | Sommersemester | Nein | % |
