Basic understanding of drug substances and drug targets
Knowledge of methods and illustrative examples of drug target identification and validation - Basic understanding of the connection between molecular and clinical effects of drug substances
Knowledge on enzyme classes and mechanisms relevant for the selective synthesis of active compounds and chemicals
Basic knowledge on enzyme screening, characterization, and selectivity
Basic knowledge on enzyme and reaction engineering
Application of proteomics methods to diseases
Basic understanding of protein based diseases
Basic understanding of approaches to diagnose protein based diseases with focus on neurological disorders
Knowledge of the basic concepts of Computational Biology and Bioinformatics
A first and transparent introduction in comparative modeling and molecular dynamics simulations
Concepts of analyzing proteins/drug targets in 3D
Principles of modeling biological data
Modulinhalte
Course B-PhBT.1: General aspects of drug target identification and validation
Definition and characteristics of drug substances
Definition and characteristics of molecular drug targets
Interaction of drug substances and drug targets
Propagation of molecular drug effects
Methods and techniques for the identification and validation of drug targets
Correlation and causality of molecular and clinical drug effects
Course B-PhBT.2: Biocatalysis for drug and chemical syntheses
What are the benefits of biocatalysis?
Enzyme classes and their relevance for the biocatalytic production of active compounds and chemicals
Basic molecular mechanisms of enzyme catalysis
Screening for suitable enzyme activities
Enzyme purification and characterization
Chirality and how it is achieved by enzymes %u2013 kinetic resolution %u2013 asymmetric synthesis
Application modes of biocatalysis %u2013 in vitro and in vivo applications
Improvement of enzyme properties
o Directed mutagenesis o Directed evolution
Basics of reaction engineering and cofactor regeneration
Examples of industrial applications
Course B-PhBT.3: Protein based diseases
General overview on diseases caused by proteins
Protein misfolding and aggregation in neurological diseases
Cerebrospinal fluid and blood biomarkers in neurodegenerative disorders
Metabolic myopathies
4. Course B-PhBT.4: Protein modeling and simulation
Introduction to Bioinformatics and comparative/homology modeling
Introduction in sequence alignment techniques
Analyzing protein structures
Commonly used force fields for protein simulations
Introduction to Molecular Dynamics
Introduction to docking simulations
Lehrveranstaltungsformen
Seminar (9 SWS)
Kursus
Unterrichtsprachen
Deutsch, Englisch
Dauer in Semestern
1 Semester Semester
Angebotsrhythmus Modul
jedes Wintersemester
Aufnahmekapazität Modul
unbegrenzt
Prüfungsebene
Credit-Points
10 CP
Modulabschlussnote
LV1: %; LV2: %.
Faktor der Modulnote für die Endnote des Studiengangs
