PHA.06112.02 - B-InBT: Introduction to Chemical Biotechnology (Complete module description)
PHA.06112.02 - B-InBT: Introduction to Chemical Biotechnology (Complete module description)
PHA.06112.02
10 CP
Module label
B-InBT: Introduction to Chemical Biotechnology
Module code
PHA.06112.02
Semester of first implementation
Faculty/Institute
Institut für Pharmazie
Module used in courses of study / semesters
Pharmaceutical and Industrial Biotechnology (MA120 LP) (Master) > Pharmazie PharmacIndusBiotech.MA120, Version of accreditation valid from WS 2019/20 > Spezialisierung Industrial Biotechnology
Pharmaceutical and Industrial Biotechnology (MA120 LP) (Master) > Pharmazie PharmacIndusBiotech.MA120, Version of accreditation (WS 2015/16 - SoSe 2023) > Spezialisierung Industrial Biotechnology
Responsible person for this module
Further responsible persons
B. Junker
Prerequisites
Skills to be acquired in this module
Basic knowledge of natural products (terpenes, fatty acids, proteins, carbohydrates and selected alkaloids)
- Basic knowledge of daily occurring products (fibers, dyes, tensides, selected drugs, renewable resources) - Knowledge on enzyme classes and mechanisms relevant for the selective synthesis of active compounds and chemicals - Basic knowledge on enzyme screening, characterization, and selectivity - Basic knowledge on enzyme and reaction engineering - Basic knowledge of methods in top-down systems biology (-omics methods, statistics) - Basic knowledge of methods in bottom-up systems biology (modeling and simulation of biological networks) - Basic knowledge of the principles and objectives of metabolic engineering - Basic knowledge of methods in metabolic engineering (gene identification, gene isolation, gene expression and its optimization)
Module contents
Course B-InBT.1 Basics of organic chemistry of natural products
Data analysis and visualization (clustering, graphs, over-representation analysis)
Principles of mathematical modeling of biological networks
Course B-InBT.4 Basics of metabolic engineering
Why metabolic engineering? (Process optimization, production of chemicals using renewable resources, new chemicals, chemical sourcing)
Objects of metabolic engineering (biofuels, commodity chemicals/high value products) and associated constraints (regulatory, environmental, process, financial)
Methods in metabolic engineering: Gene identification and sourcing (literature and genome data mining, pathway discovery), different host types (microorganisms, algae, plants)
Engineering optimization based on metabolic modelling
Optimization based on improvement of gene expression (codon optimization, expression levels, protein stabilization, enzymatic properties)
Plant metabolic engineering: Potential, challenges and current progress
Forms of instruction
Seminar (8 SWS)
Course
Languages of instruction
German, English
Duration (semesters)
1 Semester Semester
Module frequency
jedes Wintersemester
Module capacity
unlimited
Time of examination
Credit points
10 CP
Share on module final degree
Course1: %; Course2: %.
Share of module grade on the course of study's final grade