PHA.06109.02 - B-PhBT: Drug target identification and validation (Vollständige Modulbeschreibung)

PHA.06109.02	10 CP
Modulbezeichnung	B-PhBT: Drug target identification and validation
Modulcode	PHA.06109.02
Semester der erstmaligen Durchführung
Fachbereich/Institut	Institut für Pharmazie
Verwendet in Studiengängen / Semestern	Pharmaceutical and Industrial Biotechnology (MA120 LP) (Master) > Pharmazie PharmacIndusBiotech.MA120, Akkreditierungsfassung gültig ab WS 2019/20 > Spezialisierung Pharmaceutical Biotechnology Pharmaceutical and Industrial Biotechnology (MA120 LP) (Master) > Pharmazie PharmacIndusBiotech.MA120, Akkreditierungsfassung (WS 2015/16 - SoSe 2023) > Spezialisierung Pharmaceutical Biotechnology
Modulverantwortliche/r
Weitere verantwortliche Personen	W. Sippl
Teilnahmevoraussetzungen
Kompetenzziele	Basic understanding of drug substances and drug targets Knowledge of methods and illustrative examples of drug target identification and validation - Basic understanding of the connection between molecular and clinical effects of drug substances Knowledge on enzyme classes and mechanisms relevant for the selective synthesis of active compounds and chemicals Basic knowledge on enzyme screening, characterization, and selectivity Basic knowledge on enzyme and reaction engineering Application of proteomics methods to diseases Basic understanding of protein based diseases Basic understanding of approaches to diagnose protein based diseases with focus on neurological disorders Knowledge of the basic concepts of Computational Biology and Bioinformatics A first and transparent introduction in comparative modeling and molecular dynamics simulations Concepts of analyzing proteins/drug targets in 3D Principles of modeling biological data
Modulinhalte	Course B-PhBT.1: General aspects of drug target identification and validation Definition and characteristics of drug substances Definition and characteristics of molecular drug targets Interaction of drug substances and drug targets Propagation of molecular drug effects Methods and techniques for the identification and validation of drug targets Correlation and causality of molecular and clinical drug effects Course B-PhBT.2: Biocatalysis for drug and chemical syntheses What are the benefits of biocatalysis? Enzyme classes and their relevance for the biocatalytic production of active compounds and chemicals Basic molecular mechanisms of enzyme catalysis Screening for suitable enzyme activities Enzyme purification and characterization Chirality and how it is achieved by enzymes %u2013 kinetic resolution %u2013 asymmetric synthesis Application modes of biocatalysis %u2013 in vitro and in vivo applications Improvement of enzyme properties o Directed mutagenesis o Directed evolution Basics of reaction engineering and cofactor regeneration Examples of industrial applications Course B-PhBT.3: Protein based diseases General overview on diseases caused by proteins Protein misfolding and aggregation in neurological diseases Cerebrospinal fluid and blood biomarkers in neurodegenerative disorders Metabolic myopathies 4. Course B-PhBT.4: Protein modeling and simulation Introduction to Bioinformatics and comparative/homology modeling Introduction in sequence alignment techniques Analyzing protein structures Commonly used force fields for protein simulations Introduction to Molecular Dynamics Introduction to docking simulations
Lehrveranstaltungsformen	Seminar (9 SWS) Kursus
Unterrichtsprachen	Deutsch, Englisch
Dauer in Semestern	1 Semester Semester
Angebotsrhythmus Modul	jedes Wintersemester
Aufnahmekapazität Modul	unbegrenzt
Prüfungsebene
Credit-Points	10 CP
Modulabschlussnote	LV 1: %; LV 2: %.
Faktor der Modulnote für die Endnote des Studiengangs	1

Modulveranstaltung	Lehrveranstaltungsform	Veranstaltungstitel	SWS	Workload selbstgestaltete Arbeit	Workload Summe
LV 1	Seminar	Project seminar	9		0
LV 2	Kursus	Private study			0
Workload modulbezogen				300	300
Workload Modul insgesamt					300

Prüfung	Prüfungsvorleistung	Prüfungsform
LV 1
LV 2
Gesamtmodul		Klausur
Wiederholungsprüfung

Regularien	Teilnahmevoraussetzungen	Angebotsrhythmus	Anwesenheitspflicht	Gewicht an Modulnote in %
LV 1		Wintersemester	Nein	%
LV 2		Wintersemester	Nein	%